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Abstract [Objective]To explore the effects of Danhong injection on the brain tissue expression of glial fibril‐lary acidic protein (GFAP) after cerebral ischemic reperfusion (IR) in rats .[Methods]A cerebral ischemia‐reperfu‐sion rat model was established through an occlusion of middle cerebral artery .A total of 96 healthy male Sprague‐Dawley rats were randomly divided into 4 groups of normal control ( n =8) ,sham operation ( n =8) ,ischemia reperfusion ( n =40) and Danhong injection ( n=40) .The expressions of GFAP in brain tissue were detected by immunohistochemistry at 6h ,24h ,48h ,72h and 7d post‐IR in ischemia‐reperfusion and Danhong intervention groups .Before sacrificing ,the neurological deficit scores were evaluated for all rats .The experimental results were analyzed with Spss17 .0 .[Results]The expressions of GFAP were weak in both normal control and sham op‐eration groups .And the levels of GFAP were evidently up‐regulated at 6h and peaked at 72h ( P <0 .05) .Then there was a gradual decline .Compared with ischemia/reperfusion group ,the levels of GFAP evidently decreased in Danhong intervention group ( P<0 .05) .At 24h ,48h ,72h and 7d ,the neurological deficit score of Danhong in‐tervention group was better than that of ischemia/reperfusion group .And the neurological deficit scores decreased in Danhong group ( P<0 .05) .[Conclusion]After ischemia‐reperfusion injury ,the levels of GFAP were evidently up‐regulated in ischemia‐reperfusion rats .Injury of brain tissue after ischemia‐reperfusion is blunted in Danhong intervention group .And Danhong may down‐regulate the level of GFAP and suppress the excessive proliferation of astrocytes .
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2015, Vol. 32 
