|
|
|
| Clinical Study of Olanzapine Combined with Metoclopramide to Treat Explosive Chemotherapy-induced Nausea and Vomiting |
| ZHOU Chun-xiang%CHEN Li-zhang%MA Jin-an |
|
|
|
|
Abstract [Objective] To retrospectively analyze the efficacy of olanzapine combined with metoclopramide to treat explosive chemotherapy‐induced nausea and vomiting in patients with malignant tumor cancer receiving moderately and highly emetogenic chemotherapy .[Methods] Patients with malignant cancer receiving moder‐ately and highly emetogenic chemotherapy(platinum and anthracyclines) were chosen .Among 68 patients with explosive nausea and vomiting after conventional anti‐vomiting treatment before chemotherapy ,46 patients with highly emetogenic chemotherapy were treated with conventional anti‐vomiting therapy i .e .palonosetron 0 .25mg intravenously at d1 and dexamethasone 10mg intravenously once daily at d1~3 30min after chemothera‐py ,and 22 patients with moderately emetogenic chemotherapy were treated with conventional anti‐vomiting therapy i .e .ondansetron 8mg intravenously at d1~2 and dexamethasone10mg intravenously at d1~3 .When ex‐plosive nausea and vomiting appeared , all patients were given metoclopramide 20mg intramuscularly and olanzapine 10mg orally once daily for 3 days .The remission of nausea and vomiting and other adverse events at 0~24h after mediation were observed .[Results] A total of 68 patients with explosive nausea and vomiting af‐ter chemotherapy were treated .The efficacy was assessed .The complete remission(CR) rate of explosive vomiting and nausea were 80 .9% (55/68) and 75 .0% (51/68) ,respectively .The main side effects were drowsiness(13 .2% ,9/68) ,fatigue(10 .3% ,7/68) and dizziness(7 .4% ,5/68) and so on .No obvious grade 3~4 toxic reaction was found .[Conclusion]Metoclopramide combined with olanzapine for treating explosive nausea and vomiting induced by moderately and highly emetogenic chemotherapy had good efficacy without ob‐vious toxic and side reaction .Therefore ,it is worthy of clinical promotion .
|
|
|
|
|
|
|
|
|
2015, Vol. 32 
