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Abstract [Objective]To evaluate the level of urinary mindin in elder patients with type 2 diabetes melli‐tus (T2DM ) and analyze its association with renal injury .[Methods]From October 2012 to June 2013 ,a total of 168 T2DM patients were recruited and divided into three groups of normoalbuminuria (urinary albumin <30 mg/24h ,n=70) ,microalbuminuria (30 ≤ urinary albumin <300 mg/24h ,n=50) and macroalbuminuria (u‐rinary albumin >300 mg/24h ,n =48) .And 50 age and gender‐matched subjects were selected into normal control group .The levels of urinary mindin ,blood & urinary creatinine ,serum urea nitrogen ,cystatin C , blood glucose ,glycated hemoglobin and C‐peptide ,etc .were measured .[Results]The levels of urinary mindin were significantly higher in the macroalbuminuria ,microalbuminuria and normoalbuminuria groups than those of control group [435(227~905) ,327(179~406) ,163(117~223) & 91(50~120) L?ng/mL? μmol re‐spectively ;F=31 .037 ,P <0 .05] .With rising 24 h‐UAE ,the level of urinary mindin also showed a trend of increase (r=0 .461 ,P<0 .05) .The urinary level of mindin was positively correlated with urea nitrogen ,cre‐atinine ,cystatin C ,blood glucose ,24 h‐urinary albumin and course of T2DM while negatively correlated with estimated glomerular filtration rate .Logistic regression analysis showed that urinary mindin ,diastolic blood pressure and fasting blood‐glucose were independent influencing factors of renal injury in T2DM .[Conclusion]Urinary mindin is probably closely correlated with diabetic nephropathy and participates in the progress of dia‐betic nephropathy .And it may serve as a potential marker for an early diagnosis of diabetic nephropathy .
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2015, Vol. 32 
