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Abstract [Objective]To explore the expression and clinical significance of miR‐26a in childhood B‐cell a‐cute lymphoblastic leukemia (ALL) .[Methods]Bone marrow samples were collected from 38 children with B‐cell ALL and 18 controls with non‐hematologic diseases .Total RNA was harvested from bone marrow .Real‐time polymerase chain reaction (PCR) was performed to detect the expression level of miR‐26a .[Results]The relative expression level of miR‐26a was remarkably lower in B‐cell ALL group than that in controls ( P <0 .05) .And the expression of miR‐26a in newly diagnosed samples was lower than those in Day 30 and Week 12 samples respectively ( P <0 .05) .Also its expression in Day 30 samples was lower than those in Week 12 samples ( P<0 .05) .And its expression in children aged over 10 years old was significantly lower than those in children aged under 10 years ( P <0 .05) .Its expression was higher in low‐risk group than those in middle and high‐risk groups respectively ( P <0 .05) .There was significant difference between middle and high‐risk groups ( P <0 .05) .[Conclusion]miR‐26a has tumor suppressor effect so that it may become a potential prog‐nostic biomarker for childhood B cell ALL .
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2015, Vol. 32 
