|
Abstract [Objective]To explore the serum activity changes of cathepsin D (CATD) and alpha‐1 antitryp‐sin (AAT) in different stages of osteoarthritis patients .[Methods]The serum samples were collected from 20 patients with stagesⅠ ~ Ⅳ knee osteoarthritis according to the Kellgren‐Lawrence (K‐L) criteria .And anoth‐er 20 healthy controls were also recruited .Enzyme‐linked immunosorbent assay (ELISA) was used to detect the serum activities of CATD and AAT .The data were analyzed by SPSS19 .0 software to determine whether the serum activities of CATD and AAT had changed or not for different stages of osteoarthritis and whether the differences were significant compared with healthy controls .[Results]Compared with healthy sera ,the ser‐um activity of CATD increased for stages Ⅰ ~ Ⅱpatients while that of CATD decreased for stages Ⅲ ~ Ⅳ ones .As for serum activity of AAT ,stagesⅠ ~ Ⅱincreased while stages Ⅲ ~ Ⅳhad no statistical difference com‐pared with healthy sera .[Conclusion]The serum activities of CATD and AAT vary during different stages of osteoarthritis .And testing these two serum enzymes may help to determine the degeneration degree of osteoar‐thritis cartilage in patients with osteoarthritis .
|
|
|
|
|
|
2015, Vol. 32 
