|
Abstract [Objective]To explore the clinical significance of lh‐plasma glucose (1hPG) cutoff value during oral glucose tolerance test (OGTT) in the screening of abnormal glucose metabolism on hypertension patients .[Methods]A total of 112 hypertension patients were recruited for OGTT .The cutoff value of 1hPG during OGTT was analyzed by receiver operating characteristic (ROC) curve .The tangent point value was used to di‐vide them into two groups .And their values of height ,weight ,body mass index (BMI) ,fasting plasma glu‐cose (FPG) ,triglycerides (TG) ,cholesterol (CHO) ,high & low density lipoprotein cholesterol (HDL‐c &LDH‐c) ,blood uric acid (UA) ,HOMA‐IR and HOMA‐β were measured and compared .[Results](1) A‐mong them ,30 cases (26 .8% ) had normal glucose tolerance (NGT) while 46 cases (41 .1% ) impaired glucose regulation (IGR) .There were 36 new cases (32 .1% ) of diabetes ;(2) According to the results of ROC ,for diagnosing abnormal glucose metabolism ,the optimal cutoff value of 1hPG during OGTT was 10 .1 mmol/L with a sensitivity of 89% and a specificity of 90% ;(3) .In group of 1hPG ≥10 .1 mmol/L ,UA ,FPG and HOMA‐IR index were all higher than those in group of <10 .1 mmol/L ( P <0 .05) while HOMA‐β index was lower than group of <10 .1 mmol/L ( P <0 .05) .No statistic difference existed between two groups in BMI ,FTI ,TG ,CHO ,LDL‐c or HDL‐c .[Conclusion]Hypertension patients with 1hPG ≥10 .1 mmol/L are more likely to have abnormal glucose metabolism .And lh PG may reflect insulin resistance and islet β‐cell function .
|
|
|
|
|
|
2015, Vol. 32 
