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Abstract [Objective] To explore the clinicopathological features ,histological types ,diagnosis ,differen‐tial diagnosis ,treatment and prognosis of type AB thymoma with liver metastases .[Methods]Liver metasta‐sis specimens were harvested from one 49‐year‐old female case of type AB thymoma 5 years after operation and examined histologically with light microscopy and immunohistochemistry .Comprehensive analyses were con‐ducted for clinical manifestations ,histopathology ,immunohistochemical features ,differential diagnosis ,treat‐ment and prognosis after initial operation .The pathological diagnosis for liver metastases was type AB thy‐moma .Immunohistochemical staining showed CKpan (+ ) ,CD3(+ ) ,CD2 (+ ) ,TdT (+ ) ,CD5 (+ ) ,p53 (+ ) ,Hep‐1 (-) and Ki67‐positive cells (25% ~30% ) .The expression level of galectin‐3 was higher than that in mediastinal thymoma tissue identified 5 years ago .[Conclusion]Liver metastases of type AB thymoma are extremely rare .Type AB thymoma with low malignant potential may recur and develop distant metastases . Overexpressions of p53 ,galectin‐3 and Ki67 in type AB thymoma might coordinately manipulate the process of development ,progression and malignant transformation .
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2015, Vol. 32 
