|
|
|
| Characterization and Expression of Interleukin-6 in Remodeling of Nasal Mucosa in Allergic Rhinitis |
| FENG Hui-jie%BAI Su-juan%LI Wen-xiu |
|
|
|
|
Abstract [Objective]To explore the nasal mucosa remodeling and determine the changes in expression of interleukin‐6 (IL‐6) in patients with allergic rhinitis (AR) .[Methods]A total of 40 middle turbinate tissues samples were obtained from 15 healthy subjects ,15 AR patients and 10 AR asthmatics .The infiltration of eo‐sinophils in nasal mucosa and the damage of epithelium were examined by hematoxylin and eosin staining (HE) .Goblet cell hyperplasia was counted by alcian blue‐periodic acid‐Schiff (AB‐PAS) double staining .The extracellular matrix (ECM) was stained by masson's trichrome (MT) .And the percentage of stained EMC ar‐ea was processed by the software and transferred into Microsoft Excel for statistical analyses .The level of in‐terleukin 6 (IL‐6) in middle turbinate tissues was measured by enzyme‐linked immunosorbent Assay (ELISA) .[Results]The eosinophil infiltration ,goblet cells ,epithelial damage ,ECM deposition and level of IL‐6 signifi‐cantly increased in AR patients versus control group ( P < 0 .05) .Yet the extent of eosinophil infiltration , ECM deposition and the expression of IL‐6 were much higher in AR asthmatics than those of AR non‐asthmat‐ics ( P<0 .05) .[Conclusion] The remodeling of nasal mucosa is evident in AR patients .And IL‐6 plays some roles during tissue remodeling .Furthermore asthma may influence upper airway remodeling .
|
|
|
|
|
|
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2015, 32(1): 144-145. |
|
|
|
|
2015, Vol. 32 
