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Abstract [Objective] To explore the changes of epithelial cell proliferation and apoptosis in gallstones with different distributions and properties and investigate the role of intestinal barrier function in gallstone for‐mation .[Methods]According to different distributions of gallstones ,there were normal control group (A1 ,n=20) ,gallbladder group (B1 ,n=36) ,bile duct group (C1 ,n=36) and combined group of gallbladders com‐plicated with bile duct (D1 ,n=36) .Also on the basis of different properties of gallstones ,there were normal control group (A2 ,n=20) ,cholesterol stone group (B2 ,n = 40) ,pigment stone group (C2 ,n =52) and combination calculus group of cholesterol stone complicated with pigment stone (D2 ,n =16) .The histology changes of terminal ileum mucosa and the rate of proliferation and apoptosis in intestinal mucosa cells were measured and analyzed .[Results] According to different distributions of gallstones ,no significant difference existed in pathohistology of intestinal mucosa injury and rate of proliferation and apoptosis among A1 ,B1 ,C1 and D1 groups .While with different properties of gallstones ,pathohistology of intestinal mucosa injury and rate of proliferation and apoptosis showed higher levels in C2 group versus B2 and A2 groups ( P≤0 .05) .But no difference existed between C2 and D2 groups ( P > 0 .05) .[Conclusion] Pigment stone has the grading changes of intestinal mucosa injury in pathohistology and proliferation and apoptosis in intestinal mucosa cells . And a probable correlation exists between pigment stone formation and damaged function of intestinal mucosal barrier .It is possible that this kind of intestinal injury play some roles in the pigment stone formation .
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2015, Vol. 32 
