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Abstract To explore the significance of micro-inflammatory state factors high-sensitivity C-reactive protein(hs-CRP) ,interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α) in the diagnosis of ear-ly diabetic nephropathy(DN) .[Methods]A total of 77 patients diagnosed as type 2 diabetes mellitus(T2DM ) according to the WHO criteria in 1999 were chosen .According to urinary albumin excretion rate (UAER) ,all patients were divided into normal UAER group (NDM group ,UAER< 30mg/24h) ,early DN group (group EDN ,UAER = 30-300mg/24h ,continuous micro-albuminuria state) and clinical DN group (group CDN , UAER>300mg/24h ,continuous great albuminuria state ) .Other 33 healthy subjects were chosen as group CON .Above micro-inflammatory factors in all subjects were measured .[Results] The levels of hs-CRP in group EDN and group CDN were significantly higher than those in group CON and group NDM ( P <0 .01) . The levels of IL-6 in group EDN and group CDN group were significantly higher than those in group CON ( P<0 .01) .The levels of TNF-αin 3 experimental groups were significantly higher than those in group CON ( P<0 .01) ,and there were significant differences among 3 experimental groups( P <0 .01) .[Conclusion] The early micro-inflammatory state factors hs-CRP ,TNF-αand IL-6 in DN patients are elevated ,which indicates that inflammation occurs in early nephropathy of diabetic patients .
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2014, Vol. 31 
