|
Abstract To explore the changes of estrogen level and bone density among postmenopausal women with type 2 diabetes mellitus(T2DM ) and osteoporosis (OP) and their correlation .[Methods] Postm-enopausal women were divided into T2DM group(group T ,n=62) ,T2DM with osteoporosis group(group P , n =58) and normal control group(group N ,n=60) .Bone metabolism ,glucose metabolism ,sex hormone and other indicators among three groups were compared .[Results]Bone alkaline phosphatase(sBAP) ,osteocalcin (sOC) ,type I collagen cross-linked C end peptide(sCTx) and urine type I collagen cross-linked N end peptide (uNTx) of group P were obviously lower than those of group T .Compared with group T and group N ,serum FSH and LH were elevated ,but E2 was decreased in group P( P <0 .05) .Correlation analysis showed that bone mineral density (BMD) had significantly negative correlation with the duration of diabetes ,age ,HbA1C , FPG ,FSH ,LH and uNTx/Cr ,but no correlation with sBAP ,sOC and sCTx .[Conclusion]Osteoporosis of postmenopausal women with T2DM is related to glucose metabolism and estrogen level .
|
|
|
|
|
|
2014, Vol. 31 
