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Abstract To explore the treatment method of paraquat poisoning and analyze the influential factors of prognosis .[Methods]Clinical data of 34 patients with paraquat poisoning admitted to our hospital from Aug .2011 to May 2013 were analyzed retrospectively .All patients were divided into survival group and death group .The effect of the poisoning concentration ,first vomiting time ,the visiting time ,first perfusion time and complications on the prognosis was compared between two groups .The changes of paraquat concen-tration and superoxide dismutase(SOD) before and after blood perfusion were measured .[Results] Of 34 pa-tients ,10 patients survived(survival group) and 24 patients died (death group) ,and the mortality rate was 70 .59% .Plasma levels of paraquat after blood perfusion were obviously decreased ,but SOD activity was obvi-ously increased ,and there was significant difference between before and after blood perfusion ( P<0 .05) .The poisoning dose in the death group was obviously more than that in the survival group ,but the first vomiting time in the death group was obviously earlier than that in the survival group ,and there was significant differ-ence between two groups( P<0 .05) .The visiting time and first blood perfusion time in the death group were obviously later than those in the survival group ,and there was significant difference between two groups ( P<0 .05) .The incidence of complications in the death groups is higher than that in the survival group ,and there was significant difference between two groups( P<0 .05) .[Conclusion] Emergent first-aid measure should be performed as quickly as possible for patients with paraquat poisoning .Many factors can affect the prognosis . The poisoning doses ,SOD activity ,the concentration of paraquat ,first vomiting time ,the visiting time ,first blood perfusion time and complications are the very critical for the prognosis .Therefore ,early comprehensive treatment to deal with patients with paraquat poisoning should be taken in clinical practice .
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2014, Vol. 31 
