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Abstract To explore the expression of metastasis associated gene (Mta-1) in thyroid tumor and its correlation with tumor angiogenesis .[Methods] Paraffin-embedded tissue samples from 160 cases of thyroid tumor were selected .Among them ,120 cases were thyroid cancer and 40 cases were thyroid adenoma .Other 50 cases of normal thyroid tissue were selected .The expression of Mta-1 and microvessel count (MVC) were detected by using immunohistochemical SP method .The correlation between Mta-1 and tumor angiogenesis was analyzed .[Results]The positive expression rate of Mta-1 and MVD value in thyroid cancer were obviously higher than those in normal thyroid and thyroid adenoma ,and there was significant difference( P<0 .05) .The positive expression of Mta-1 and MVD in 120 cases of thyroid cancer were closely related to lymph node metastasis ,peplos integrity and TNM stage ( P <0 .05) ,but not related to other clinicopathological indicators ( P > 0 .05) .There was positive correlation between Mta-1 expression and MVD( r =0 .625 ,P < 0 .01) .[Conclusion]Abnormal expression of Mta-1 is closely related with the occurrence ,infiltration ,lymph node metastasis and other malignant potentials of thyroid cancer ,and may in-volve in tumor neo-angiogenesis of thyroid cancer .
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2014, Vol. 31 
