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Abstract To explore the effect of serum total homocysteine (tHcy ) on macroangiopathy in patients with type 2 diabetes mellitus(T2DM ) .[Methods] Totally 1441 T2DM patients from 29 tertiary grade A hospitals in Shanghai ,Beijing ,Guangdong ,Nanjing ,Liaoning ,Tianjin and Zhejiang were collected .The Fasting serum tHcy was measured .All patients received physical examination .The levels of blood glucose , blood lipids and vitamin B6 were also measured .The related data of diabetic complications were obtained by questionnaire survey .[Results]The incidence rate of diabetic macroangiopathy was 16 .17% (233/1441) .Ser-um tHcy level of the group with complications was (14 .28 ± 8 .76)μmol/L ,which was significantly higher than that of the group without complications[(11 .55 ± 5 .50)μmol/L]( P <0 .001) .After adjustment for age and sex ,the odds ratio(OR) value of diabetic macroangiopathy in the group with serum tHcy >15μmol/L was 2 .345(95% CI 1 .665 to 3 .302) ,and that of diabetic coronary artery diseases was 1 .932(95% CI 1 .104~3 .380) ,and that of diabetic cerebrovascular diseases was 2 .056(95% CI 1 .331~3 .176) ,and that of diabetic peripheral vascular diseases was 3 .004(95% CI 1 .656~5 .450) .[Conclusion] Hyperhomocysteinaemia can in-crease the risk of macroangiopathy in patients with T 2DM .
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2014, Vol. 31 
