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Abstract To explore the expression of matrix metalloproteinase-9(MMP-9) and human leuko-cyte differentiation antigen-34(CD34) in bladder urothelial carcinoma and its significance .[Methods] The ex-pression of MMP-9 and CD34-labelled microvessel density (MVD) in 60 cases of bladder urothelial carcinoma and 15 cases of normal bladder were measured by S-P immunohistochemical method .[Results]The expression rate of MMP-9 and the average CD34-labelled MVD in bladder urothelial carcinoma were 58 .33% (35/60) and 20 .91 ± 8 .83 respectively ,which were obviously higher than those in normal bladder tissues [6 .67% (1/15) and (9 .49 ± 2 .730 ,respectively)] ,and there was significant difference between two groups( P <0 .01) .The expression rate of MMP-9 and the average CD34-labelled MVD in bladder urothelial carcinoma were correlated with the degree of histological differentiation ,invasion depth(clinical stage) and tumor size( P <0 .05) ,but not correlated with single or multiple tumor ,age and sex( P > 0 .05) .The CD34-labelled MVD in patients with positive expression of MMP-9 was increased with the intensity of MMP-9 expression ,and there was posi-tive correlation between them ( P <0 .01) .[Conclusion] MMP-9 expression and CD34-labelled MVD in blad-der urothelial carcinoma are increased obviously ,and can be used to be the important indicators of malignancy and prognosis of bladder urothelial carcinoma .
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2014, Vol. 31 
