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Abstract To explore clinical value of Copeptin ,acute physiology and chronic health evaluation II (APACHE II) in the evaluation of the prognosis of acute paraquat poisoning (APP) .[Methods]Totally 126 pa-tients with APP were selected .When clinical death during hospital stay was taken as the endpoint ,all patients were divided into survival group( n =58) and death group( n=68) .Venous blood 3ml of all patients was drawn at 2h ,24h and 7d after admission .The level of Copeptin was detected .APACHE Ⅱ score was also continuously recorded .[Results] The poisoning dose in death group was significantly greater than that in survival group ,while there was no significant difference in rescue time ,first time of hemoperfusion and perfusion frequency ( P>0 .05) . The level of Copeptin in death group at 2h after admission was significantly higher than that in survival group ( P<0 .05) ,while there was no significant difference in APACHE Ⅱ score between two groups ( P >0 .05) .The level of Copeptin in survival group at 24h after admission was decreased to the normal ,but that in death group was still significantly higher than that in survival group ( P < 0 .05) ,and there was no significant difference in A-PACHE Ⅱ score between two groups( P>0 .05) .The level of Copeptin in death group at 7d after admission was continuously decreased ,but APACHE Ⅱ score was increased obviously ,and there was significant difference be-tween two groups( P <0 .05) .Oral dose of pesticides in patients with APP was positively correlated with Copep-tin and APACHE Ⅱ score .[Conclusion]Continuous measurement of Copeptin and APACHEⅡ score has impor-tant clinical significant in the evaluation of the prognosis of patients with APP and reasonable distribution of medi-cal resources .
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2014, Vol. 31 
