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Abstract To explore the expressions of CD133 and CK19 in nasopharyngeal carcinoma and their clini-copathological significance .[Methods]Immunohistochemical method was used to detect the expressions of CD 133 and CK19 in 112 cases of nasopharyngeal carcinoma and 20 cases of normal tissues .Clinical significance was analyzed .[Re-sults]The expression of CD133 in nasopharyngeal carcinoma was higher than that in normal tissue ,and there was sig-nificant difference between primary carcinoma and metastatic carcinoma ( P < 0 .01) ,but there was no significant difference in the expression of CD133 among groups with different age ,sex ,pathological type and cervical lymph node metastasis .There was no significant difference in the expression of CK 19 between nasopharyngeal carcinoma tissues and normal tissues( P<0 .01) ,but there was significant difference between primary carcinoma and metastatic carci-noma or cervical lymph node metastasis and no cervical lymph node ( P<0 .01) .[Conclusion]CD133 may play an im-portant role in the induction of nasopharyngeal carcinoma metastasis ,and can be regarded as one of the specific mark-ers of nasopharyngeal carcinoma stem cells .CK19 expression is associated with tumor metastasis ,but not suitable to be used as the specific maker of nasopharyngeal cancer stem cells .
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2014, Vol. 31 
