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| Clinical Significance of the Detection of Serum Cystatin C,CA125 and Osteoprotegerin in Pa-tients with Coronary Heart Disease |
| SUN Shuo%XIAO Chuang-qing%SHI Jian |
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Abstract Objective To explore the changes of serum levels of cystain C (CysC) ,CA125 and osteoprote-gerin(OPG) in patients with coronary heart disease(CHD) and their clinical significance .[Methods]A total of 158 CHD patients in our hospital were chosen as experimental group .Other 95 healthy subjects were chosen as healthy control group .Serum levels of CysC ,CA125 and OPG were compared among different groups and dis-eased vessels by using immunoturbidimetry ,chemiluminescence immunoassay and ELISA .[Results] Com-pared with healthy control group ,serum levels of CysC ,CA125 and OPG in CHD group were obviously in-creased( P <0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG in single ,double and multiple vessel disease groups were gradually increased ,while left ventricular ejection fraction (LVEF) was gradually de-creased ,and there was significant difference( P<0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG level in NYHA Ⅰ ,Ⅱ ,Ⅲ and Ⅳ groups were gradually increased ,but LVEF was gradually decreased ,and there was significant difference( P <0 .05 or P <0 .01) .Serum levels of CysC ,CA125 and OPG were posi-tively correlated with the number of coronary disease vessels and cardiac function classification ( P <0 .01) , and negatively correlated with LVEF ( P <0 .01) .[Conclusion] Serum levels of CysC ,CA125 and OPG can not only evaluate the degree of cardiac function impairment ,but also is helpful for early diagnosis of CHD ,as-sessment of the severity of coronary artery disease and prognosis .
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2014, Vol. 31 
