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| Role of Bispectral Index for Guiding Propofol Dosage in Drug Abuse Patients Undergoing Painless Induced A-bortion |
| LIAO Xiao-yun%KONG Gao-yin%YE Fang-f an |
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Abstract Objective To monitor bispectral index (BIS) of drug abuse patients undergoing painless induced abortion in or-der to find proper propofol dosage for drug abuse patients .[Methods]A total of 20 drug abuse patients undergoing painless in-duced abortion in our hospital from 2009 to 2013 were randomly selected as experiment group ,while 20 non-drug abuse patients undergoing painless induced abortion were selected as control group .Human chorionic gonadotropin(HCG) was positive before the operation .Intrauterine pregnancy was confirmed by B-ultrasound .All patients were fast for 4 to 6 hours before the proce-dure .After positioned in lithotomy position ,BIS monitoring apparatus was connected to correct position and propofol TCI pump .The initial target-controlled concentration in plasma was 4μg/mL and regulated by BIS value ,hemodynamics and body movement of patients with 0 .3~0 .5μg/mL per time .When BIS maintained 45 to 60 ,eyeash reflex disappeared and no body movement after forceps clip for uterus was found ,the operation began .The mean arterial pressure(MBP) ,heart rate(HR) , SpO2 and BIS before anesthesia(T0 ) ,when eyeash reflex disappearance/no body movement after forceps clip(T1 ) ,at the be-ginning of curettage after uterine dilation(T2 ) ,after operation(T3 ) and at anesthesia recovery (T4) were recorded .Propofol TCI pump was checked after the operation .Total propofol dosage and maintenance plasma target-controlled concentration were recorded .The number of body movement ,respiratory depression ,operation time and recovery time were also recorded .[Re-sults]Under the anesthesia depth with the same value of BIS ,there was significant significance between two groups ( P <0 .05) .The propofol dosage in experiment group was (179 ± 51)mg ,which was obviously higher than that in control group [(124 ± 27)mg] .The recovery time in experiment group was obviously shorter than that in control group ,and there was sig-nificant difference( P <0 .05) .There was no significant difference in the number of body movement and respiratory depression between two groups( P >0 .05) .[Conclusion] Propofol dosage for drug abuse patients undergoing painless induced abortion with maintenance plasma target-controlled concentration of (6 .8 ± 1 .4)μg/mL is markedly higher than that for non-drug abuse patients ,but the recovery time is obviously shorter than that for non-drug abuse patients .
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2011, 28(7): 1405-1406. |
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2014, Vol. 31 
