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Abstract Objective To explore the correlation of plasma homocysteine (Hcy) level with the occurrence and devel-opment of type 2 diabetes mellitus(T2DM) .[Methods] Plasma Hcy ,fasting glucose(FPG) ,glycosylated hemoglobin (HbA1c) and urine microalbumin(UMALB) in 42 T2DM patients(T2DM group) and 64 patients with impaired fasting glucose(IFG)(IFG group) were measured and compared with those in 86 healthy subjects(control group) .The correlation of Hcy with FPG ,HbA1c and UMALB was analyzed .[Results] Plasma levels of Hcy ,HbA1c ,FPG and UMALB in T2DM group were higher than those in control group significantly ( P <0 .05) .The average values of FPG ,Hcy and UMALB in IFG group were higher than those in control group significantly ( P<0 .05) .HbA1C was increased slightly , but there was no significant difference ( P>0 .05) .Pearson correlation analysis showed that Hcy was positively correlated with FPG( r =0 .465 ,P<0 .05) ,HbA1c( r =0 .246 ,P<0 .05) and UMALB( r =0 .775 ,P<0 .05) .[Conclusion]Plasma Hcy level is closely related with the occurrence and development of T 2DM .The detection of Hcy in patients with IFG is of important significance for preventing T 2DM .
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2014, Vol. 31 
