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Abstract Objective To explore the role of calcitonin gene-related peptide(CRGP) in endothelial progen-itor cells(EPCs) inhibiting the proliferation of vascular smooth muscle cells (VSMCs) induced by angiotensin II (AngII) .[Methods] The expression of CGRP in EPCs was determined by using ELISA .EPCs condition me-dium was blocked by CGRP antibody .The effect of EPCs condition medium on DNA synthesis ability ,total protein level ,cell survival and cell cycle induced by AngII was observed .[Results]EPCs could express and se-cret high level of CGRP .After CGRP blockage ,the inhibitory effect of EPCs condition medium on AngII-in-duced DNA synthesis ability ,total protein level ,cell survival and cell cycle progression of VSMCs was lower than that in control group( P<0 .05) .[Conclusion]EPCs inhibits the proliferation of VSMCs induced by An-gII through the paracrine secretion of CGRP .
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2014, Vol. 31 
