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Abstract Objective To explore the efficacy and prognostic factors of comprehensive therapy for hypopharyngeal carcinoma .[Methods]Clinical data of 70 patients with hypopharyngeal carcinoma in our hospital from June 2008 to Oct . 2010 were analyzed retrospectively .According to 2002 international union against cancer (UICC) staging standard ,3 pa-tients were stageⅠ,and 10 patients were stageⅡ ,and 22 patients were stage Ⅲ and 35 patients were stage IV .According to different treatment methods ,70 patients were divided into radical intensity modulated radiation therapy plus chemother-apy group(group A ,n=30) and surgery plus postoperative routine radiation group (group B ,n=40) .Radiotherapy was given 2~4 weeks after the complete healing of postoperative wound .[Results] The 1-,3- and 5-year overall survival rates of all 70 patients were 82 .9% (58/70) ,61 .5% (43/70) and 38 .5% (27/70) ,respectively .The local control rates of group A and group B were 66 .7% (20/30) and 70 .0% (28/40) respectively ,but there was no significant difference be-tween two groups( P>0 .05) .The 1-,3-and 5-year overall survival rates of group A and group B were 83 .3% (25/30) ,63 .0% (19/30) ,38 .0% (11/30) ,82 .5% (33/40) ,58 .5% (23/40) and 39 .0% (15/40) respectively ,but there was no significant difference between two groups ( P>0 .05) .[Conclusion]Radical intensity modulated radiation therapy combined with chemotherapy can not only obtain the same efficacy as surgery ,but also keep the laryngeal function of pa-tients and improve the quality of life .
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2014, Vol. 31 
