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Abstract Objective To explore the effect of tanshinone on cerebral perfusion and hemodynamics of vaso-spasm(CVS) after subarachnoid hemorrhage(SAH) .[Methods]Totally 200 SAH patients in our hospital were randomly divided into control group( n=100) and observation group( n=100) .The control group received nimo-dipine for the treatment of CVS ,while the observation group received tanshinone for the treatment of CVS on the basis of the treatment of control group .Cerebral perfusion and hemodynamic changes were observed and compared between two groups .[Results]Cerebral blood flow (CBF) and cerebral blood volume(CBV) of the cortex of frontal lobe and temporal lobe in observation group after treatment were markedly higher than those in control group , while the mean transit time(MTT) in observation group was less than that in control group ,and there was signifi-cantdifferencebetweentwogroups(P < 0.05).Erythrocytesedimentationrate(ESR),fibrinogen(Fb),blood viscosity under low shear rate(nbl) and blood viscosity under high shear rate(nbh) in observation group after treat-ment were lower than those in control group ,and there was significant difference( P<0 .05) .[Conclusion] Tan-shinone can effectively enhance the dilation of cerebral vessels ,improve blood viscosity and platelet aggregation , increase cerebral blood flow ,ameliorate cerebral perfusion and reduce the incidence of CVS .
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2014, Vol. 31 
