Abstract Objective To explore the protective effect of morphine postprocessing on myocardial ischemia/reperfu-sion injury(I/R) in rats .[Methods]A total of 40 male healthy SD adult rats were randomly divided into 4 groups with 10 rats in each group .Sham group(S group) only underwent thoracotomy ,and left anterior descending coronary artery was separated ,and blood flow was not blocked for 150min .The I/R group(IR group) underwent the blockage of left anterior descending coronary artery for 30min ,and then the reperfusion for 120min .Morphine postprocessing 1 group(M1 group) received morphine 0 .1mg/kg within 1min immediately after ischemia ,and then the reperfusion for 120min .Morphine postprocessing 2 group(M2 group) received morphine 0 .3mg/kg within 1min immediately after ischemia ,and then the reperfusion for 120min .At the end of the reperfusion ,the infarct size(IS) was measured .The expression of cytochrome C oxidase(CcO) in myocardium was detected by Western blotting .[Results] Compared with IR group ,the IS in M1 group and M2 group were decreased( P <0 .05) .The IS in M2 group was decreased more obviously than that in M1 group ,and there was significant difference( P<0 .05) .The expression of CcO in M1 group and M2 group were increased ( P<0 .05) .[Conclusion]Morphine postprocessing has protective effect on myocardial I/R injury which may be related to the promotion of CcO expression in myocardium .
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