|
Abstract [Objective]To explore the clinical efficacy of calcium dobesilate combined with olmesartan for the treatment of proteinuria in diabetic nephropathy (DN) .[Methods]A total of 70 DN patients with proteinu-ria in our hospital from Feb .2012 to April 2013 were randomly divided into observation group ( n =35) and control group( n=35) .The control group received regular treatment including olmesartan and other hypogly-cemic hypotensive treatment .The observation group was additionally given calcium dobesilate based on the treatment of control group .The 24h-urinary albumin excretion rates(UAER) ,monocyte chemotactic protein-1 (MCP-1) and urinary α1-microglobulin(α1-MG) before and 12 weeks after treatment were compared between two groups .[Results] The 24h-UAER in observation group after 12 weeks of treatment was decreased more obviously ,and there was significant difference( P <0 .05) .The total effective rate of observation group was 88% ,which was markedly higher than that of control group(68% ) ,and there was significant difference( P<0 .05) .[Conclusion]Calcium dobesilate combined with olmesartan for the treatment of proteinuria in DN has good efficacy and safety .
|
|
|
|
|
|
2014, Vol. 31 
