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| Preliminary Study on the Indications for Gallbladder-preserving Cholelithotomy |
| NANG Yun-guang%DING Hai-bo%LIU Da-lin |
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Abstract [Objective] To explore the correlation of gallbladder contraction dysfunction and cholecystokinin (CCK ) A re-ceptor(AR) with gallbladder stone in order to provide the theoretical basis for identifying the indications of gallbladder-preser-ving cholelithotomy .[Methods]Type-B ultrasound was used to measure gallbladder wall thickness ,length ,width and trans diameter in gallbladder polyps group and stone groups .Gallbladder contraction efficiency was calculated .Enzyme immunohis-tochemical method was used for staining .The expression of CCK-AR in gallbladder wall was observed .[Results]The thick-ness of gallbladder wall in gallbladder stone group was obviously higher than that in gallbladder polyps group ( P <0 .05) . Gallbladder contraction efficiency in gallbladder stone group was obviously lower than that in gallbladder polyps group ( P <0 .05) .There was significantly negative correlation between gallbladder contraction efficiency and the thickness of gallbladder wall in gallbladder stone group .The expression of CCK-AR in gallbladder stone group was lower than that in gallbladder pol-yps group( P<0 .0) .There was significantly positive correlation between gallbladder contraction efficiency and the cell num-ber of positive expression of CCK-AR in smooth muscle of gallbladder stone group .[Conclusion]Gallbladder contraction effi-ciency is associated with the decreasing of CCK-AR .There is negative correlation between gallbladder wall thickness and gall-bladder contraction efficiency in patients with gallbladder stone .The basic conditions for gallbladder-preserving cholelithotomy are gallbladder contraction efficiency>50% and gallbladder wall thickness<0 .30cm .
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2014, Vol. 31 
