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Abstract [Objective] To explore the correlation between interleukin-1β(IL-1β) rs16944 gene polymor-phism and type 2 diabetes mellitus(T2DM ) .[Methods] The extraction genomic DNA and MassARRAY mole-cule weight array were used to analyze the gene polymorphism of IL-1βin healthy control group(n=366) and 583 T2DM patients .[Results]The distribution frequencies of 3 genotypes AA ,AG and GG of IL-1βin healthy control group were 22 .40% ,50 .00% and 27 .60% respectively ,while those inT2DM group were 20 .58% , 50 .09% and 29 .33% , respectively . The distribution frequencies of allele A in healthy control group and T2DM group were 47 .40% and 45 .63% ,respectively .The distribution frequencies of allele G in healthy con-trol group and T2DM group were 52 .60% and 54 .37% ,respectively .There was no significant difference in each genotype and allele genotype between two groups ( P>0 .05) .[Conclusion]IL-1βrs16944 gene polymor-phism is probably independent of T2DM in Liaoning province .
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2014, Vol. 31 
