使用蒽环类药物化疗的恶性肿瘤患者发生慢性心脏毒性的影响因素分析

doi:10.3969/j.issn.1671-7171.2024.04.020

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Abstract 【Objective】To explore the influencing factors of chronic cardiotoxicity in patients with malignant tumors treated with anthracycline chemotherapy. 【Methods】The clinical data of 64 patients with malignant tumors treated with anthracyclines in two hospital were collected. According to whether the patients had chronic cardiotoxicity within 1 year of chemotherapy, they were divided into toxic group (25 cases) and non-toxic group (39 cases). The baseline data, ECG abnormalities, cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) levels of patients in the two groups were compared. The influencing factors of chronic cardiotoxicity in patients were analyzed by using receiver operating characteristic (ROC) curve and multivariate logistic regression. 【Results】The levels of cTnI, CK-MB and LDH in the toxic group were higher than those in the non-toxic group, and the incidence of ECG abnormalities in the toxic group was higher than that in the non-toxic group (P<0.05). ROC analysis showed that cTnI, CK-MB and LDH could be used to evaluate the occurrence of chronic cardiotoxicity in patients, and the areas under the curve were 0.746, 0.889 and 0.785, respectively (P<0.05). Multivariate logistic regression analysis confirmed that cTnI>84.430 ng/mL, CK-MB>28.692 IU/L, LDH>203.292 IU/L, ST-T segment changes, T wave abnormalities, sinusachycardia, atrioventricular block were the risk factors of chronic cardiotoxicity (P<0.05).【Conclusion】 cTnI>84.430 ng/mL, ST-T segment changes, CK-MB>28.692 IU/L, LDH>203.292 IU/L, T wave abnormalities, sinus tachycardia, atrioventricular block are the risk factors of chronic cardiotoxicity in patients treated with anthracycline chemotherapy, which can provide a reliable reference for early clinical intervention.

Key words： Neoplasms/DT Anthracyclines/TO Cardiotoxicity Root Cause Analysis

Received: 10 March 2023

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	PENG Meiling
	ZHANG Xuemei

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PENG Meiling,ZHANG Xuemei. Influencing Factors of Chronic Cardiotoxicity in Patients with Malignant Tumors Treated with Anthracycline Chemotherapy[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 551-554.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.04.020 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I4/551

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