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| The Expression Level and Clinical Significance of FLT-1 and YKL-40 in Serum of Children with Respiratory Syncytial Virus Positive |
| YE Wen-juan, WANG Yu |
| Department of Pediatric, Baoji Hospital Affiliated of Xi'an Medical College, Baoji Shaanxi 721000 |
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Abstract 【Objective】To investigate the expression level and clinical significance of human vascular endothelial growth factor receptor-1 (FLT-1) and human chitinase protein 40 (YKL-40) in the serum of children with respiratory syncytial virus (RSV) positive.【Methods】From March 2019 to April 2021, 82 children with RSV positive were treated in Baoji Hospital affiliated to Xi'an Medical College. All children were given recombinant human interferon α-2b For injection therapy, RSV positive children were divided into effective group and ineffective group according to the clinical efficacy. The general data of the two groups of children were collected, and the factors influencing the clinical efficacy of RSV positive children were analyzed by Logistic multivariate regression, and the predictive value of serum FLT-1 and YKL-40 levels on the clinical efficacy of RSV positive children was analyzed by using the subject working characteristic (ROC) curve.【Results】 Among 82 cases of RSV positive children in this study, 59 cases (71.95%) in the effective group and 23 cases (28.05%) in the ineffective group; The children in the effective group were older than those in the ineffective group, and the levels of FLT-1 and YKL-40 were lower than those in the ineffective group, the difference was statistically significant (P<0.05); Multivariate regression analysis showed that young children and high serum levels of FLT-1 and YKL-40 were risk factors for ineffective treatment in RSV positive children (P<0.05); The ROC curve analysis results showed that the area under the ROC curve (AUC) of serum FLT-1 and YKL-40 levels predicting the clinical efficacy of RSV positive children were 0.803(95%CI:0.710-0.895) and 0.778 (95%CI:0.669-0.888), respectively. 【Conclusion】The young RSV positive children with high serum FLT-1 and YKL-40 levels are more likely to have poor clinical efficacy, and both have certain predictive value for the clinical efficacy of RSV positive children.
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Received: 29 July 2022
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2023, Vol. 40 
