121例儿童神经母细胞瘤的临床特点及预后影响因素分析<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2023.11.001

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Abstract 【Objective】To investigate the clinical characteristics and prognostic factors of neuroblastoma(NB) in children. 【Methods】A retrospective analysis was conducted on the clinical data of 121 children with NB admitted to our hospital from January 2019 to September 2022. The Kaplan Meier method was used for univariate analysis to calculate the average survival time of each group of patients,and the Log-rank test was used to analyze the differences in survival rate among groups. The Cox regression model was used for multivariate analysis to analyze the independent risk factors affecting the survival rate of children,and the correlation between NB clinical factors and survival time and outcome was analyzed. 【Results】Log-rank test analysis showed that gender,LDH,NMYC amplification,MKI index,INSS stage,COG risk group,and histological type were factors affecting the survival time of children(P<0.05). Multivariate analysis using the Cox regression model showed that LDH≥500 U/L,NMYC gene amplification,and INSS stage 4 were independent risk factors affecting the survival prognosis of children(P<0.05). 【Conclusion】NMYC amplification and INSS stage 4 are risk factors affecting the prognosis of children with NB;detecting serum LDH is of great significance for evaluating the prognosis of children with NB.

Key words： Neuroblastoma/PA Prognosis Root Cause Analysis

Received: 23 March 2023

PACS:

R730.264.4

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.11.001 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I11/1617

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