Application Value of Serum Amyloid A and Prealbumin in Evaluating Therapeutic Efficacy and Prognosis of Patients with Acute Respiratory Infection
FAN Linpenga, LU Lingb, GUO Yunboc
The Second Affiliated Hospital of Zhengzhou University: a. RICU; b. Department of Geriatric Medicine; c. Department of Respiratory and Critical Care Medicine, Zhengzhou Henan 450000
Abstract：【Objective】 To explore the application value of serum amyloid A (SAA) and prealbumin (PA) levels in evaluating therapeutic efficacy and prognosis of patients with acute respiratory infection (ARI). 【Methods】 A total of 500 patients with ARI treated in our hospital from February 2023 to February 2025 were retrospectively analyzed. According to pathogen test results, patients were divided into viral infection group (n=238) and bacterial infection group (n=262). Based on disease severity, they were classified into mild group (n=182), moderate group (n=149) and severe group (n=169). In accordance with clinical outcomes, patients were divided into good prognosis group (n=407) and poor prognosis group (n=93). The levels of SAA and PA in each group were detected and compared. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive efficiency of SAA and PA for the severity of ARI. Logistic regression analysis was adopted to identify influencing factors of poor prognosis in ARI patients. 【Results】 The level of SAA in bacterial infection group was higher than that of viral infection group, while PA level was lower, with statistically significant differences (P<0.05). As the severity of ARI aggravated, SAA level increased progressively and PA level decreased gradually, and intergroup differences were statistically significant (P<0.05). ROC curve analysis showed that combined detection of SAA and PA exhibited superior predictive efficiency for ARI severity compared with single indicator (P<0.05). The proportions of patients with bacterial infection, severe illness and lower respiratory tract infection were higher in poor prognosis group (P<0.05). Inflammatory indicators including SAA and white blood cell (WBC) count, C-reactive protein (CRP) were significantly higher, while PA was markedly lower in poor prognosis group (all P<0.05). Infection type, disease severity, infection site, SAA level, PA level, WBC count and CRP were independent influencing factors for poor prognosis of ARI patients. 【Conclusions】 The changes of serum SAA and PA levels possess important clinical value in judging therapeutic efficacy and predicting prognosis of patients with acute respiratory infection.
范林鹏, 芦玲, 郭云波. 血清淀粉样蛋白A、前白蛋白在急性呼吸道感染患者治疗效果与预后评估中的应用价值[J]. 医学临床研究, 2026, 43(7): 1116-1119.
FAN Linpeng, LU Ling, GUO Yunbo. Application Value of Serum Amyloid A and Prealbumin in Evaluating Therapeutic Efficacy and Prognosis of Patients with Acute Respiratory Infection. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1116-1119.
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2026, Vol. 43 
