硝苯地平控释片与苯磺酸氨氯地平片对清晨高血压患者的降压效果及血压变异性的影响比较

doi:10.3969/j.issn.1671-7171.2026.04.019

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摘要 【目的】比较硝苯地平控释片与苯磺酸氨氯地平片对清晨高血压患者的降压效果及血压变异性的影响。【方法】选择2021年4月至2024年4月本院收治的109例清晨高血压患者,采用随机数字表法将患者分为A组(服用硝苯地平控释片,n=54)和B组(服用苯磺酸氨氯地平片,n=55),两组均治疗12周。比较两组患者的疗效、不良反应发生率,以及治疗前后清晨收缩压(SBP)、清晨舒张压(DBP)、清晨血压达标率、血压变异性。【结果】A组、B组总有效率分别为96.30%(52/54)、92.73%(51/55)。两组总有效率比较,差异无统计学意义(χ²=0.667,P=0.414)。治疗4周、8周及12周,两组患者清晨DBP、SBP均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。治疗4周、8周时,两组患者清晨血压达标率比较,差异均无统计学意义(P>0.05);治疗12周时,B组清晨血压达标率显著高于A组,差异有统计学意义(P<0.05)。治疗后,两组患者的收缩压变异性(SBPV)、舒张压变异性(DBPV)均显著低于治疗前,且B组显著低于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ²=0.724,P=0.394)。【结论】硝苯地平控释片与苯磺酸氨氯地平片均可有效降低清晨血压,但苯磺酸氨氯地平片在稳定血压水平、提高清晨血压达标率及降低血压变异性方面效果更佳。

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	芦玲
	柯亚琼
	范林鹏

关键词 ：高血压, 硝苯地平, 氨氯地平, 降压, 控制性

Abstract：【Objective】 To compare the antihypertensive effects and impacts on blood pressure variability between nifedipine controlled-release tablets and amlodipine besylate tablets in patients with morning hypertension. 【Methods】 A total of 109 patients with morning hypertension admitted to our hospital from April 2021 to April 2024 were enrolled and randomly divided into group A (treated with nifedipine controlled-release tablets, n=54) and group B (treated with amlodipine besylate tablets, n=55). Both groups were treated for 12 weeks. The clinical efficacy, incidence of adverse reactions, morning systolic blood pressure (SBP), morning diastolic blood pressure (DBP), morning blood pressure target achievement rate, and blood pressure variability before and after treatment were compared between the two groups. 【Results】 The total effective rates of group A and group B were 96.30% (52/54) and 92.73% (51/55), respectively, with no statistically significant difference (χ²=0.667, P=0.414). At 4, 8, and 12 weeks of treatment, morning DBP and SBP in both groups were lower than those before treatment, and those in group B were lower than group A (P<0.05). There was no significant difference in morning blood pressure target achievement rate between the two groups at 4 and 8 weeks (P>0.05); at 12 weeks, the rate in group B was significantly higher than that in group A (P<0.05). After treatment, systolic blood pressure variability (SBPV) and diastolic blood pressure variability (DBPV) in both groups were significantly lower than those before treatment, and those in group B were significantly lower than group A (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ²=0.724, P=0.394). 【Conclusion】 Both nifedipine controlled-release tablets and amlodipine besylate tablets can effectively reduce morning blood pressure, but amlodipine besylate tablets perform better in stabilizing blood pressure, improving the morning blood pressure target achievement rate and reducing blood pressure variability.

Key words： Hypertension Nifedipine Amlodipine Hypotension, Controlled

收稿日期: 2026-01-09

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R544.1

引用本文:

芦玲, 柯亚琼, 范林鹏. 硝苯地平控释片与苯磺酸氨氯地平片对清晨高血压患者的降压效果及血压变异性的影响比较[J]. 医学临床研究, 2026, 43(4): 595-598.
LU Ling, KE Yaqiong, FAN Linpeng. Comparison of Antihypertensive Effects and Impacts on Blood Pressure Variability between Nifedipine Controlled-Release Tablets and Amlodipine Besylate Tablets in Patients with Morning Hypertension. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 595-598.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.04.019 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I4/595

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