Abstract：【Objective】 To investigate the clinical effect of target-controlled infusion (TCI) of remifentanil combined propofol in endoscopic mucosal resection (EMR) of colorectal lesions. 【Methods】 A total of 86 patients undergoing EMR were randomly divided into a control group (propofol TCI alone) and an observation group (remifentanil combined with propofol TCI). The quality of anesthesia, pain intensity [visual analogue scale (VAS)], mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2) before induction, at scope insertion, and 5 minutes after surgery, as well as the incidence of adverse events were compared between the two groups. 【Results】 The time to achieve adequate sedation was shorter and the maintenance rate of target sedation was higher in the observation group than in the control group (both P<0.05). The incidence of intraoperative body movement and hypoxemia was lower in the observation group compared to the control group (P<0.05). At scope insertion, MAP and HR in the observation group were lower than those in the control group, while at 5 minutes postoperatively, MAP, HR, and SpO2 in the observation group were higher than those in the control group (P<0.05). VAS scores at 2 h and 24 h postoperatively were lower than those at 5 minutes after leaving the operating room in both groups (P<0.05). However, there were no statistically significant differences in VAS scores between the two groups at 5 minutes, 2 h, or 24 h postoperatively (P>0.05). The overall incidence of adverse reactions was lower in the observation group than in the control group (P<0.05). 【Conclusion】 Compared with propofol TCI alone, remifentanil combined with propofol TCI in EMR significantly improves sedation and analgesia quality, reduces body movement and hypoxemic events, enhances perioperative physiological stability, and decreases the incidence of adverse events.
陶凤禹, 王志春. 瑞芬太尼联合丙泊酚靶控输注在结直肠内镜下黏膜切除术中的应用效果[J]. 医学临床研究, 2026, 43(3): 399-402.
TAO Fengyu, WANG Zhichun. Application of Target-Controlled Infusion of Remifentanil Combined with Propofol in Endoscopic Mucosal Resection of Colorectal Lesions. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 399-402.
2026, Vol. 43 
