血液灌流联合血液透析治疗抗抑郁药物急性中毒患者的疗效

doi:10.3969/j.issn.1671-7171.2025.06.029

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摘要【目的】探讨血液灌流联合血液透析治疗抗抑郁药急性中毒患者的疗效。【方法】82例抗抑郁药急性中毒患者随机分为对照组和观察组,每组41例。对照组给予血液透析治疗,观察组行血液灌流联合血液透析治疗,两组患者均持续治疗3 d。比较两组患者治疗前后心功能、心肌酶、炎症因子、肝及肾功能指标的变化和并发症发生情况。【结果】治疗后,观察组左室射血分数高于对照组,左心室舒张末内径、左心室收缩末内径低于对照组(P<0.05)。观察组肌酸磷酸激酶、乳酸脱氢酶、肌酸激酶同工酶水平,C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平,谷丙转氨酶、谷草转氨酶和尿素氮水平均显著低于对照组(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。【结论】血液灌流联合血液透析治疗抗抑郁药急性中毒患者的疗效显著,可有效改善患者心、肝、肾功能,减轻心肌损伤,抑制炎症因子的合成,且安全性良好。

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	闫学政

关键词 ：抗抑郁药, 中毒, 肾透析, 血液灌注, 治疗结果

Abstract：【Objective】To investigate the efficacy of hemoperfusion combined with hemodialysis in the treatment of patients with acute antidepressant poisoning.【Methods】A total of 82 patients with acute antidepressant poisoning were randomly divided into the control group and the observation group, with 41 patients in each group. Patients in the control group received hemodialysis treatment, while those in the observation group received treatment of hemoperfusion combined with hemodialysis. Both groups were treated continuously for three days. Changes in cardiac function, myocardial enzymes, inflammatory factors, gastrointestinal and renal function indicators before and after treatment, as well as the incidence of complications, were compared between the two groups.【Results】After treatment, the observation group showed a higher left ventricular ejection fraction and lower left ventricular end-diastolic diameter and left ventricular end-systolic diameter compared to the control group (P<0.05). Levels of creatine kinase, lactate dehydrogenase, creatine kinase-MB, C-reactive protein, interleukin-6, tumor necrosis factor-α, alanine aminotransferase, aspartate aminotransferase, and blood urea nitrogen were all significantly lower in the observation group than in the control group (P<0.05). There was no statistically significant difference in the overall incidence of complications between the two groups (P>0.05).【Conclusion】Hemoperfusion combined with hemodialysis is highly effective in treating patients with acute antidepressant poisoning. It can significantly improve cardiac function, reduce myocardial damage, enhance gastrointestinal and renal function, and inhibit the synthesis of inflammatory factors, with good safety.

Key words： Antidepressive Agents Poisoning Renal Dialysis Hemoperfusion Treatment Outcome

收稿日期: 2023-12-27

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R595.4

引用本文:

闫学政. 血液灌流联合血液透析治疗抗抑郁药物急性中毒患者的疗效[J]. 医学临床研究, 2025, 42(6): 1015-1018.
YAN Xuezheng. Efficacy of Hemoperfusion Combined with Hemodialysis in the Treatment of Acute Antidepressant Poisoning. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1015-1018.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.06.029 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I6/1015

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