Abstract：【Objective】To investigate the expression and clinical significance of interleukin-17 (IL-17) in tissue and peripheral blood of perianal abscess,anal fistula.【Methods】Select 50 patients with primary perianal abscess admitted to our hospital from January 2022 to December (observation group),and divide them into rehabilitation group (no recurrence or occurrence of anal fistula) and anal fistula group (progression to anal fistula) based on the follow-up results of 6 months after surgery. Select 50 patients with mixed hemorrhoids who underwent surgical treatment in our hospital during the same period (control group). According to the positive expression of IL-17 protein in the observation group,patients were divided into a positive group and a negative group. Record the postoperative follow-up of patients in the observation group,and compare the expression levels of IL-17 protein and IL-17 mRNA in the anal and rectal tissues between different groups.【Results】The positive expression rate of IL-17 protein in the observation group was significantly higher than that in the control group,with a statistically significant difference (P<0.01). The proportion of abscess diameter ≥ 5 cm,wound surface healing time ≥ 4 weeks,and progression to anal fistula in the IL-17 protein positive expression group was higher than that in the IL-17 protein negative expression group; The difference was statistically significant (P<0.05). The expression level of IL-17 mRNA in the observation group was higher than that in the control group with a statistically significant difference (P<0.001). Patients in the observation group were followed up for 6 months after surgery; And the result showed that IL-17 mRNA expression level in the anal fistula group was higher than that in the rehabilitation group with a statistically significant difference (P=0.014).【Conclusion】The positive expression rate of IL-17 protein and the expression level of IL-17 mRNA are high in patients with perianal abscess and anal fistula. IL-17 plays an important role in the occurrence and development of perianal abscess and anal fistula.
2023, Vol. 40 
