Abstract：【Objective】 To investigate the expression level of methylated CpG binding protein 2 (MeCP2) and tenascin C (TNC) in uterinemyoma and its clinical significance. 【Methods】 A total of 109 patients with hysteromyoma treated in the Shaanxi Rehabilitation Hospital from January 2019 to September 2021 were selected as the observation group, and 68 patients who underwent hysterectomy for uterine prolapse in the same period were selected as the control group. The basic data of the two groups of patients were collected, and the expression of MeCP2 and TNC protein in uterinemyoma tissue, adjacent tissue of uterinemyoma in the observation group and uterine smooth muscle tissue in the control group were detected by immunohistochemical method. The expression of MeCP2 and TNC protein in uterine leiomyoma tissue and adjacent tissue of patients with uterine leiomyoma was analyzed, and the influencing factors of uterine leiomyoma were analyzed. At the same time, the relationship between MeCP2 and TNC levels and uterine leiomyoma diameter in the observation group was also analyzed. 【Results】 The positive expression rates of MeCP2 and TNC in uterine leiomyoma were higher than those in adjacent tissues (P<0.05). Logistic regression analysis showed that menstrual disorder (OR:3.892, 95%CI:1.576~9.611), the number of abortions (OR:4.293, 95%CI:1.739~10.601), MeCP2 positive (OR:4.495, 95%CI:2.218~9.110), TNC positive expression (OR:4.341, 95%CI:2.142~8.796) were the influencing factors of hysteromyoma (P<0.05). The positive expression rates of MeCP2 and TNC in patients with hysteromyoma ≥ 5 cm were higher than those in patients with hysteromyoma <5 cm (P<0.05). 【Conclusion】The occurrence of uterinemyoma is related to the expression of MeCP2 and TNC in uterine smooth muscle tissue, and its expression level may be related to the diameter of uterinemyoma.
安凤婷, 刘夏炎. MeCP2和TNC在子宫肌瘤组织中的表达水平及其临床意义[J]. 医学临床研究, 2022, 39(7): 1061-1064.
AN Feng-ting, LIU Xia-yan. Expression Level of MeCP2 and TNC in Uterinemyoma and its Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1061-1064.
[1] GIULIANI E,AS-SANIE S,MARSH E E. Epidemiology and management of uterine fibroids[J].Int J Gynaecol Obstet,2020,149(1):3-9.
[2] 王秀娟,任益平. 单孔腹腔镜下“棒球缝合法”在子宫肌瘤剥除术中的应用价值[J].医学临床研究,2021,38(6):949-951.
[3] ROCCA M L,PALUMBO A R,LICO D,et al. Relugolix for the treatment of uterine fibroids[J].Expert Opin Pharmacother,2020,21(14):1667-1674.
[4] LIANG M R,ZENG Y,ZENG S Y,et al. The expression of MBD6 is associated with tumor size in uterine leiomyomas[J].Genet Test Mol Biomarkers,2019,23(8):523-532.
[5] JAMALUDDIN M F B,NAGENDRA P B,NAHAR P,et al.Proteomic analysis identifies tenascin-C expression is upregulated in uterine fibroids[J].Reprod Sci,2019,26(4):476-486.
[6] 刘菊英,阎臻,聂文静. 肌腱蛋白C在宫颈癌中的表达及与临床特征及预后的关系[J].癌症进展,2020,18(1):76-79.
[7] 杨倩,李颖,王璐,等. 脆性组氨酸三联体、甲基-CpG-结合蛋白2异常表达与宫颈癌变的关系及交互作用[J].中华流行病学杂志,2018,39(5):689-693.
[8] 赵寅生,周昌莉,蔡春林,等. 肌腱蛋白C在直肠癌及胃癌组织中的表达及临床意义[J].安徽医科大学学报,2017,52(10):1528-1530.
[9] 子宫肌瘤的诊治中国专家共识专家组. 子宫肌瘤的诊治中国专家共识[J].中华妇产科杂志,2017,52(12):793-800.
[10] TAKALA H,YANG Q,EL RAZEK A M A,et al. Alcohol consumption and risk of uterine fibroids[J].Curr Mol Med,2020,20(4):247-258.
[11] ALEKSANDROVYCH V,PASTERNAK A,GIL K. Telocytes in the architecture of uterine fibroids[J].Folia Med Cracov,2019,59(4):33-44.
[12] XIANG Y,TANAKA Y,PATTERSON B,et al. Dysregulation of BRD4 function underlies the functional abnormalities of MeCP2 mutant neurons[J].Mol Cell,2020,79(1):84-98.
[13] RODRIGUES D C,MUFTEEV M,ELLIS J. Regulation,diversity and function of MECP2 exon and 3'UTR isoforms[J].Hum Mol Genet,2020,29(R1):89-99.
[14] SHA H,ZHANG D,ZHANG Y,et al. ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin-C via Wnt/β-catenin pathway[J].Mol Med Rep,2017,16(3):3641-3647.
2022, Vol. 39 
