Abstract：【Objective】 To investigate the effect of muscle relaxation on the surgical conditions of elderly women with uterine fibroids (leiomyoma). 【Methods】 A total of 86 patients who underwent laparoscopic myomectomy in our hospital from January 2010 to November 2017 were selected and divided into the control group and the observation group according to random number table, with 43 cases each. Both groups of patients underwent continuous infusion of cis-atracurium to maintain muscle relaxation. In the observation group, the target muscle relaxation degree was TOF1-2 (moderate muscle relaxation, i.e. four series of stimulation can maintain 1-2 muscle twitch). In the control group, the target degree of muscle relaxation was PTC1-2 (deep muscle relaxation, i.e. 1-2 monostimulatory twitch after tetanic stimulation). Operating conditions, endotracheal intubation conditions, recovery of muscle relaxants, surgeon score, and incidence of adverse reactions were compared between the two groups. 【Results】 There was no significant difference in operative time and surgeon score between the observation group and the control group (P>0.05). The mean pneumoperitoneal pressure and the extubation time in the observation group were higher than those in the control group. The ratios of 4 string stimulations (TOFr) recovery to 0.7 and 0.9 in the observation group were shorter than those in the control group (P<0.05) . The excellent and good rate of tracheal intubation was 100.00% in both groups. The total incidence of adverse reactions in the two groups was 6.96% and 4.64%, respectively, with no significant difference (P>0.05). 【Conclusion】 The treatment of TOF1-2 muscle relaxant in elderly women with uterine fibroids can obtain better operating conditions and tracheal intubation conditions. The recovery time of muscle relaxant is short. There were no obvious adverse reactions, which can be further popularized and used in clinical practice.
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2018, Vol. 35 
