摘要【目的】探讨原血小板碱性蛋白(PPBP)、人中性粒细胞肽1-3(HNP 1-3)与冠心病的相关性。【方法】前瞻性选择2013年1月至2016 年12月本院心内科收治的70例男性冠心病患者(冠心病组),另纳入35例男性健康体检者作为对照组。应用酶光度比色法检测两组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C),采用酶联免疫吸附法检测PPBP、HNP 1-3水平。【结果】冠心病组与对照组血清HDL-C比较,差异无统计学意义( P >0.05);冠心病组年龄、TC、TG、LDL-C显著高于对照组,差异具有统计学意义( P <0.05)。冠心病组血浆PPBP、HNP 1-3水平均显著高于对照组,差异具有统计学意义( P <0.05)。血浆PPBP、HNP 1-3与年龄、TC、LDL-C呈显著正相关( P <0.05),与TG,HDL无相关性( P >0.05)。【结论】PPBP、HNP 1-3是潜在的炎症标志物,可能预示高脂血症患者冠心病的发病风险。
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2018, Vol. 35 
