摘要【目的】探讨血清炎症因子水平变化对急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)治疗后发生再狭窄的影响。【方法】回顾性分析2015年3月至2016年3月本院收治的120例AMI 患者的临床资料,根据术后冠脉造影复查结果将其分为再狭窄组( n =41,出现血管再狭窄)和非再狭窄组( n =79,未出现血管再狭窄)。检测并比较两组患者术前、术后3 d、术后7 d血清血管内皮生长因子(VEGF)、超敏C反应蛋白(hs-CRP)、妊娠相关蛋白A(PAPP-A)、基质金属蛋白酶-9(MMP-9)及白细胞介素-10(IL-10)水平变化。【结果】再狭窄组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著的高于非再狭窄组,血清高密度脂蛋白胆固醇(HDL-C)水平低于非再狭窄组,差异具有统计学意义( P <0.05)。术前,再狭窄组和非再狭窄组患者的血清VEGF、hs-CRP、PAPP-A、MMP-9、IL-10水平比较,差异均无统计学意义( P >0.05);术后d3、d7再狭窄组血清VEGF、hs-CRP、PAPP-A、MMP-9、IL-10水平均显著高于非再狭窄组,差异具有统计学意义( P <0.05)。【结论】AMI患者PCI术后血清VEGF、hs-CRP、PAPP-A、MMP-9、IL-10水平升高,对再狭窄的发生有一定的影响。
Abstract：【Objective】 To investigate the effect of changes of serum inflammatory factors on restenosis after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 【Methods】 The clinical data of 120 patients with AMI from March 2015 to March 2016 were analyzed retrospectively. According to the results of coronary angiography, the patients were divided into restenosis group ( n =41) and non-restenosis group ( n =79). The serum levels of vascular endothelial growth factor (VEGF), hypersensitive C-reactive protein (hs-CRP), pregnancy-associated protein A (PAPP-A), matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10) were measured and compared between the two groups. 【Results】The levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) in the restenosis group were significantly higher than those in the non restenosis group. The serum high density lipoprotein cholesterol (HDL-C) level was significantly lower in the restenosis group than in non restenosis group ( P < 0 05). There was no significant difference in the serum levels of VEGF hs-CRP PAPP-AMP 9 IL-10 between the restenosis group and the non-restenosis group before operation ( P > 0.05), and on the third and 7th day after operation, the serum levels of VEGF hs-CRP PAPP-AMP 9 IL-10 in the restenosis group were significantly higher than those in the non-restenosis group ( P < 0.05). 【Conclusion】The level of IL-10 in serum VEGF, hs-CRP, PAPP-A,MMP- 9 and IL-10 in patients with AMI after PCI is increased, which has a certain effect on the occurrence of restenosis.
吴军. 血清炎症因子水平对AMI患者PCI术后发生再狭窄的影响[J]. 医学临床研究, 2018, 35(7): 1332-1334.
Wu Jun. Effect of Serum Inflammatory Factors on Restenosis after PCI in AMI Patients. JOURNAL OF CLINICAL RESEARCH, 2018, 35(7): 1332-1334.
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2018, Vol. 35 
