Abstract：【Objective】 To investigate the diagnostic value of interleukin -27 (IL-27) combi ned with adenosine deaminase (ADA) in the diagnosis of tuberculous pleurisy.【Methods】 Ninety cases of pleural effusion hospitalized in our hospital from May 2016 to October 2017 were selected, including 46 tuberculous pleural effusion patients (observation group) and 44 patients with other pleural effusion (control group). All of the subjects were performed pleural puncture after admission, collecting pleural effusion, separating pleural effusion supernatant, collecting peripheral venous blood at the early morning of admission, and separating serum. The content of ADA was measured by colorimetric method and the content of IL-27 was determined by enzyme linked immunosorbent assay (ELISA). The operation was determined strictly according to the specification standard of the kit. The changes of IL-27 and ADA content of pleural effusion, the changes of serum IL-27 and ADA, the combination of IL-27 and ADA, and the correlation between IL-27 and ADA were compared between the two groups. 【Results】Pleural effusion IL-27 and ADA content of the observation group were higher than those of the control group (P<0.05); the serum levels of IL-27 and ADA were higher than those of the control group (P<0.05); ADA IL-27 diagnostic sensitivity, specificity and accuracy were higher than those of IL-27 and ADA single; tuberculous pleural effusion and IL-27 ADA showed a linear positive correlation. 【Conclusion】IL-27 combined with ADA detection can improve the diagnostic efficiency of tuberculous pleurisy and can be used as an effective indicator for the diagnosis of tuberculous pleurisy.
张艳丽, 武丽, 王涛, 李福建. IL-27联合ADA检测对结核性胸膜炎的诊断价值[J]. 医学临床研究, 2018, 35(6): 1107-1109.
ZHANG Yan-li, WU Li, WANG Tao, et al. Diagnostic Value of IL-27 Combined with ADA for Tuberculous Pleurisy. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1107-1109.
2018, Vol. 35 
