Abstract：【Objective】To investigate the dosimetric characteristic of radiotherapy for peripheral non-small-cell lung cancer (NSCLC) with body γ-knife (MASEP body γ-knife) and intensity modulated radiation therapy (IMRT).【Methods】A total of 11 patients with peripheral non-small-cell lung cancer were selected in the study. Two treatment plans were designed for each patient, including γ-knife and IMRT. The total prescribed dose was 66 Gy for each patient. The planning standard was that the prescribed dose covered at least 95% of the planned target volume (PTV), and each dangerous organ dose was required to be within the tolerable dose range. The difference between the tumor target dose and the normal tissue exposure dose was compared by the isodose distribution of the target area, dose volume histogram (DVH), conformity index (CI), and heterogeneity index (HI).【Results】CI and HI of the IMRT plan were superior to the γ-knife plan . The V5, V10, V20, and V30 doses of surrounding normal tissues of the γ-knife plan were significantly lower than those of the IMRT plan (P<0.05). The maximal dose (Dmax), mean dose (Dmean), and minimum dose (Dmin) of gamma-knife PTV were better than the corresponding IMRT indicators, and the target dose was higher than the IMRT plan (P<0.05).【Conclusion】Body γ-knife treatment of peripheral non-small-cell lung cancer can significantly increase the target volume dose as well as protect the surrounding normal tissue. It has the potential to improve efficacy of comprehensive treatment.
刘利民, 苏加利, 李强, 黄高明, 吴锁如, 张修胜. 周围型非小细胞肺癌体部伽马刀和调强适形放疗的剂量学比较研究[J]. 医学临床研究, 2018, 35(6): 1041-1043.
LIU Li-min, SU Jia-li, LI Qiang, et al. Dosimetric Study of Intensity Modulated Radiation Therapy and Body Gamma-Knife Radiosurgery for Peripheral Non-small-cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1041-1043.
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2018, Vol. 35 
