支气管哮喘患儿血清25-羟基维生素D<sub>3</sub>水平变化及其与血清IgE和FeNO的相关性

doi:10.3969/j.issn.1671-7171.2018.03.030

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摘要【目的】探讨支气管哮喘患儿血清25-羟基维生素D₃[25(OH)D₃]水平变化及其与血清免疫球蛋白E(IgE)和呼出气一氧化氮(FeNO)的相关性。【方法】选取支气管哮喘患儿108例,按随机数表法分为观察组和对照组,每组54例。另外选取同期儿保健康体检儿童50例(健康组)。对照组患儿给予常规治疗,观察组患儿在常规治疗基础上给予维生素D治疗3个月,比较两组疗效。同时比较受试者血清25(OH)D₃水平、总IgE水平、FeNO,并分析血清25(OH)D₃水平与血清总IgE和FeNO相关性。【结果】观察组治疗总有效率为90.74%(49/54),高于对照组的75.93%(41/54),其差异有统计学意义(P<0.05);观察组、对照组患儿血清25(OH)D₃水平显著低于健康组(P<0.05),血清总IgE水平、FeNO均显著高于健康组(P<0.05)。Pearson相关分析显示:血清25(OH)D₃水平与IgE和FeNO呈负相关(r=-0.825,P=0.001;r=-0.876,P=0.001)。【结论】补充维生素D辅助治疗可改善小儿支气管哮喘疗效;患儿血清25(OH)D₃水平与气道高反应性和机体变应反应指标(血清总IgE和FeNO)呈负相关。

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	魏杰男
	刘兰
	韩芳

关键词 ：哮喘, 维生素D/血液, 免疫球蛋白E/血液, 一氧化氮

Abstract：【Objective】To explore the efficacy of vitamin D adjuvant therapy in children with bronchial asthma and the relationship between the concentration of serum 25-hydroxyvitamin D₃[25 (OH)D₃] and the indexes (IgE and FeNO) of airway hyperresponsiveness and organism allergic response indexes.【Methods】A total of 108 children with bronchial asthma were selected for the study and randomly divided into the observation group (n=54) and the control group (n=54). In addition, 50 healthy children during the same period were selected as healthy group. The control group was given routine treatment for asthma, and the observation group was given vitamin D intervention for 3 months on the basis of routine treatment. The efficacy of the two groups was compared. At the same time, the serum levels of vitamin D₃, serum total IgE and exhaled NO (FeNO) were recorded among groups, and the relationship between serum 25 (OH)D₃level and serum total IgE and FeNO was analyzed.【Results】The total effective rate of treatment in the observation group was 90.74% (49/54), which was higher than that in the control group 75.93% (41/54); the difference was statistically significant (P<0.05). The levels of serum vitamin D₃in both control and observation groups were significantly lower than that in healthy group (P<0.05), while the total serum levels of IgE and FeNO were higher than those in healthy group (P<0.05). Pearson correlation analysis showed that serum 25 (OH)D₃level was negatively correlated with IgE and FeNO (r=-0.825, P=0.001;r=-0.876, P=0.001).【Conclusion】Vitamin D supplementation adjuvant therapy can enhance the efficacy of pediatric bronchial asthma and improve pulmonary function. Serum 25 (OH)D₃level is negatively correlated with airway hyperresponsiveness and body allergic response indexes (serum total IgE and FeNO).

Key words： Asthma Vitamin D/BL Immunoglobulin E/BL Nitric Oxide

收稿日期: 2017-07-07

PACS:

R725.622.5

引用本文:

魏杰男,刘兰,韩芳. 支气管哮喘患儿血清25-羟基维生素D₃水平变化及其与血清IgE和FeNO的相关性[J]. 医学临床研究, 2018, 35(3): 512-515.
WEI Jie-nan, LIU Lan, HAN Fang. Relationship Between Serum 25-hydroxyvitamin D₃ Concentration and Indexes (IgE and FENO) of Airway Hyperresponsiveness and Organism Allergic Response. JOURNAL OF CLINICAL RESEARCH, 2018, 35(3): 512-515.

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http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2018.03.030 或 http://www.jcr.net.cn/CN/Y2018/V35/I3/512

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