Abstract：【Objective】To explore the effects of general anesthesia combined with epidural anesthesia on coagulation function in preeclampsia patients.【Methods】A total of 60 preeclampsia patients were divided into two group, with 30 cases in each group. The control group was given general anesthesia before cesarean section, and the observation group was treated with general anesthesia combined with epidural anesthesia. The levels of MAP, HR, SpO2and APTT (activated partial prothrombin time), PT (prothrombin time), FIB (fibrinogen) and D-D (D-dimer) at the time before anesthesia (T0), after anesthesia was stable (T1), intraoperative 30min (T2), postoperative 24h (T3) were compared between the two groups. The complications were observed as well.【Results】The anesthesia induction time in the observation group was shorter and the ephedrine dosage was more than that of the control group (P<0.05), The levels of MAP and HR at the time point of T1, T2and T3were lower, and the level of SpO2at the time point of T1and T2were higher in the observation group than those in the control group (P<0.05). The APTT was longer in the observation group than in the control group at the time point of T1, T2and T3, and the levels of FIB and D-D were lower in the observation group than in the control group. There was no significant difference in the PT at each time point in the two groups (P<0.05). The incidence rate of complications related to anesthesia in the observation group was lower than that in the control group.【Conclusion】General anesthesia combined with epidural anesthesia has little influence on blood coagulation function, hemodynamic index in preeclampsia patients. It can shorten the anesthesia induction time and reduce related complications. Therefore it is worthy of clinical application.
李俊芳,郭小群. 全麻复合硬膜外麻醉对子痫前期患者凝血功能指标的影响[J]. 医学临床研究, 2018, 35(3): 507-509.
LI Jun-fang, GUO Xiao-qun. Effects of General Anesthesia Combined with Epidural Anesthesia on Coagulation Function in Preeclampsia Patients. JOURNAL OF CLINICAL RESEARCH, 2018, 35(3): 507-509.
2018, Vol. 35 
