Abstract：【Objective】To investigate the relationships of insulin resistance with metabolic syndrome and with cardiovascular events in patients with hypertension.【Methods】A total of 191 patients with hypertension in our hospital from April 2015 to August 2016 were selected as study subjects. According to the insulin resistance index, patients were divided into the simple hypertension group (the control group) and insulin-resistant hypertension group (the observation group). The systolic blood pressure, diastolic blood pressure, glucose and lipid metabolism, high sensitivity C reactive protein, and adiponectin were detected for all patients and insulin resistance indexes were calculated. The incidence of cardiovascular events were recorded through one year of follow-ups.【Results】 (1) There were statistically significant differences in blood pressure, glucose metabolism, lipid metabolism, high sensitivity C reactive protein, adiponectin, and insulin resistance indices of the two groups (P<0.05); (2) In the control group, patients with metabolic syndrome had significantly higher levels of fasting glucose and adiponectin levels than those with non-metabolic syndrome. The fasting blood glucose, adiponectin, high-sensitivity C-reactive protein and insulin resistance index of metabolic syndrome patients in the observation group were significantly higher than those in non-metabolic syndrome patients, and the levels of high-density lipoprotein cholesterol were significantly lower than those in metabolic syndrome patients (P<0.05). (3) With regards to the relationship between metabolic syndrome and metabolic risk factors; the high density lipoprotein cholesterol was negatively correlated with metabolic syndrome. Uric acid, high-sensitivity C reactive protein and insulin resistance index were positively correlated with metabolic syndrome. (4) A 1-year follow-up of patients with hypertension showed that high insulin resistance index, high triglyceride, high sensitive C reactive protein and low high density lipoprotein cholesterol had a higher probability of cardiovascular events (P<0.05).【Conclusion】Insulin resistance is significantly higher in hypertensive patients than in normal subjects. Insulin resistance is significantly associated with metabolic syndrome; insulin resistance index potentially becomes a new predictor after traditional cardiovascular risk factors such as high-density lipoprotein cholesterol, triacylglycerol, and high-sensitivity C-reactive protein.
邓于亮. 高血压患者胰岛素抵抗与代谢综合征、心血管事件的相关性分析[J]. 医学临床研究, 2018, 35(3): 489-491,494.
DENG Yu-liang. Relationships of Insulin Resistance with Metabolic Syndrome and with Cardiovascular Events in Patients with Hypertension. JOURNAL OF CLINICAL RESEARCH, 2018, 35(3): 489-491,494.
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2018, Vol. 35 
