Abstract：【Objective】To study the correlation between sleep disturbance and motor, non-motor symptoms in patients with Parkinson's disease (PD).【Methods】A total of 265 PD patients with PD from January 2016 to December 2017 were enrolled the study and divided into sleep disturbance group and non-sleep disturbance group according the score of Pittsburgh sleep quality index (PSQI). The baseline data, results of Unified Parkinson's Disease Rating Scale Ⅲ (UPDRSⅢ), H-Y stage, Montreal Cognitive Assessment (MoCA), the Scale For Outcomes in PD For Autonomic Symptoms (SCOPA-AUT), Fatigue Scale-14 (FS-14) and non-motor symptoms scale (NMSS) were compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between PSQI score and other results, and multivariate logistic regression was performed to explore the influencing factors of sleep disturbance.【Results】⑴In all 265 patients, sleep disturbance occurred in 107 cases, whose incidence was 40.4%. There were no significant differences in the baseline data including age, sex, course of disease and onset of disease between the two groups (P<0.05). ⑵The UPDRS-Ⅲ score in sleep disturbance group was significantly higher than that in the non-sleep disturbance group (P<0.05). There was significant difference in H-Y stage between the two groups, and the proportion of stage Ⅴ～Ⅵ in the sleep disturbance group was significantly higher than that in the non-sleep disturbance group (P<0.05). The result of correlation analysis showed that PSQI score of all patients had a significant positive correlation with the UPDRS-Ⅲ score and H-Y stage (r=0.216 and 0.153, P<0.05). ⑶The incidences of non-motor symptoms including orthostatic dizziness, restless legs, losing interest in things around, sad/depression, anxiety/tension, difficult concentrating, loss memory, constipation, unexplained pain and gustatory or olfactory dysfunction, SCOPA-AUT and FS-14 scores in the sleep disturbance group were significantly higher than those in the non-sleep disturbance group, and the MoCA score was significantly lower than that in the non-sleep disturbance group (P<0.05). The result of correlation analysis showed that PSQI scores were positively correlated with SCOPA-AUT and FS-14 scores (r=0.306 and 0.328, P<0.05), and negatively correlated with MoCA score (r=-0.266, P<0.05). ⑷Multivariate logistic regression showed that sad/depression, increased UPDRS-Ⅲ and SCOPA-AUT score were the independent risk factors of sleep disturbance (P<0.05), while increased MoCA score was an independent protective factor (P<0.05).【Conclusion】PD patients have high incidence of sleep disturbance, and it is not only related to motor symptom, but also closely correlated with NMS including depression, autonomic dysfunction and cognitive impairment.
2018, Vol. 35 
