二甲双胍联合达英-35治疗多囊卵巢综合征对妊娠结局的影响

doi:10.3969/j.issn.1671-7171.2018.02.016

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摘要【目的】探讨二甲双胍联合达英-35治疗多囊卵巢综合征(PCOS)的疗效及对妊娠结局的影响。【方法】选取94例胰岛素抵抗(IR)型PCOS患者,随机分为观察组和对照组,每组47例。对照组采用达英-35治疗,观察组采用达英-35联合二甲双胍治疗,治疗3个月经周期。比较两组治疗前后糖脂代谢、激素水平、子宫内膜厚度、排卵率、妊娠率和流产率。【结果】治疗后两组体质量指数(BMI)、空腹血糖 (FPG)、空腹胰岛素 (FINS)和IR水平均显著下降,且观察组下降幅度显著高于对照组(P<0.05);观察组治疗后总胆固醇(TC)和三酰甘油(TG)显著低于治疗前和对照组治疗后,差异具有统计学意义(P<0.05);治疗后两组促卵泡激素(FSH)、黄体生成素(LH)、LH/FSH、睾酮(T)显著下降,雌二醇(E₂)显著上升,子宫内膜厚度显著变薄,且观察组治疗后变化幅度大于对照组,差异具有统计学意义(P<0.05);治疗后观察组排卵率、妊娠率分别为89.36%、55.32%,显著高于对照组的68.09%、34.04%,流产率为4.26%,显著低于对照组的17.02%,其差异均有统计学意义(P<0.05)。【结论】二甲双胍联合达英-35可调节IR型PCOS患者的糖、脂代谢紊乱,降低IR,改善内分泌失调和子宫内膜异常增生,促进排卵,提高妊娠率和降低流产率,值得临床推广应用。

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	颜红丽
	邓晓红
	白昌民
	何菊仙

关键词 ：二甲双胍/药理学, 动力蛋白ATP酶/药理学, 多囊卵巢综合征, 妊娠结局

Abstract：【Objective】To analyze the effect of metformin (MET) combined with Diane-35 on pregnancy outcomes of patients with polycystic ovary syndrome (PCOS).【Methods】Ninety-four patients with insulin resistant (IR) PCOS were randomly divided into the MET group and control group, 47 cases in each group. The control group were treated with Diane-35 while the observation group were treated with Diane-35 and MET. After 3 menstrual cycles, the levels of glucose and lipid metabolism, hormone levels, endometrial thickness, ovulation rate, pregnancy rate and abortion rate were compared between the two groups before and after treatment.【Results】After treatment, the body mass index, fasting blood glucose, fasting insulin and IR levels in the two groups decreased significantly, and the decreasing range in MET group was greater than that in the control group (P<0.05). After treatment, the total cholesterol and triglyceride in MET group were significantly lower than those before treatment and those in the control group after treatment, the difference was statistically significant (P<0.05). After treatment, the follicle stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH and testosterone decreased significantly, the estradiol increased significantly, and the endometrial thickness was significantly thinner. The changes in MET group after treatment were more obvious than those in the control group (P<0.05). After treatment, the ovulation rate, pregnancy rate and abortion rate in the MET group were 89.36%, 55.32% and 4.26% while those in the control group were 68.09%, 34.04% and 17.02%, the difference was statistically significan (P<0.05).【Conclusion】Metformin combined with Dain-35 can regulate the disorder of glucose and lipid metabolism, decrease IR, improve endocrine disorders and endometrial dysplasia, increase pregnancy rate and reduce abortion rate It is worth popularizing clinical application.

Key words： Metformin/PD Dynein ATPase/PD Polycystic Ovary Syndrome Pregnancy Outcome

收稿日期: 2017-03-01

PACS:

R711.75

引用本文:

颜红丽,邓晓红,白昌民,何菊仙. 二甲双胍联合达英-35治疗多囊卵巢综合征对妊娠结局的影响[J]. 医学临床研究, 2018, 35(2): 257-259,262.
YAN Hong-li, DENG Xiao-hong, BAI Chang-min, et al. Effect of Metformin Combined with Diane-35 on Pregnancy Outcomes of Patients with Polycystic Ovarian Syndrome. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 257-259,262.

链接本文:

http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2018.02.016 或 http://www.jcr.net.cn/CN/Y2018/V35/I2/257

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