Abstract：【Objective】To analyze the changes of serum BDNF concentration and cognitive function before and after treatment of schizophrenia and its correlation.【Methods】From December 2014 to December 2016, 60 patients with schizophrenia treated in our hospital were selected as the research object, and their basic information such as their names, ages, sex, age of onset and frequency of seizures were recorded and collected The plasma of patients before and after treatment was studied. The expression of BDNF was detected by enzyme-linked immunosorbent assay (ELISA) after centrifugation. At the same time, the cognitive function of patients before and after treatment was evaluated and analyzed.【Results】Serum BDNF levels of schizophrenia patients were significantly higher than those before treatment (t=4.298, P<0.05). The WCST index of schizophrenic patients was improved after treatment (P<0.05). The evaluation of personal and social life function scale (PSP) showed that the damage was alleviated (P<0.05) compared with that before treatment. There was a positive correlation between WCST index and BDNF concentration, but no correlation was found among other indexes.【Conclusion】The serum BDNF levels of patients with schizophrenia are significantly increased after treatment, which is positively correlated with cognitive function. The treatment can improve BDNF serum concentration and improve the cognitive dysfunction of schizophrenia.
董伟,顾卫霞,唐小伟,刘鹏,赵锦同. 精神分裂症患者治疗前后血清脑源性神经营养因子浓度和认知功能的变化及其相关性[J]. 医学临床研究, 2018, 35(2): 216-218.
DONG Wei, GU Wei-xia, TANG Xiao-wei, et al. Study on the Difference of Serum Concentration and Cognitive Function Abnormalities before and after Treatment of Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 216-218.
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2018, Vol. 35 
