Abstract：【Objective】To investigate the levels of serum adiponectin (APN), fasting insulin (FINS) and high sensitive C reactive protein (hs-CRP) in patients with pregnancy induced hypertension and to analyze the correlation of APN with FINS, hs-CRP and insulin resistance (IRI).【Methods】A total of 128 pregnant women with hypertension during treatment from March 2014 to March 2017 in our hospital were selected as the observation group, including 89 cases of mild preeclampsia (mild group) and 39 cases of severe preeclampsia (severe group). Another 68 normal pregnant women at the same period were selected as the control group. FINS APN, hs-CRP. and fasting blood glucose (FBG) of all pregnant women were detected, and the IRI was calculated. The correlation of APN with FINS, hs-CRP and IRI were analyzed.【Results】Compared with the control group, the serum APN level in the mild and severe hypertension groups was significantly lower, and the levels of hs-CRP, FINS, and IRI were higher (F=8.712, 12.314, 10.698, 7.383, P=0.045, 0.023, 0.039, 0.049). Compared to the mild hypertension group, serum APN level in the severe hypertension group was significantly lower, and hs-CRP, FINS levels, and IRI were significantly higher (t=6.938, 8.856, 10.318, 5.964, P=0.045, 0.029, 0.014, 0.047). Pearson correlation analysis showed that there was a significant negative correlation of APN with FINS, hs-CRP and IRI (r=-0.289,-0.472,-0.675, P=0.034, 0.029, 0.013).【Conclusion】The expression level of APN in serum of hypertensive patients with pregnancy is decreased, and it is significantly negatively related with FINS, hs-CRP and IRI.
孙莎,袁克芳,高志敏,武丽蕊,李红霞. 妊娠期高血压患者血清脂联素、胰岛素、高敏C反应蛋白的表达水平及其意义[J]. 医学临床研究, 2018, 35(4): 684-686.
SUN Sha, YUAN Ke-fang, GAO Zhi-min, et al. Expression Levels of Serum Adiponectin, Insulin and High-Sensitivity C-reactive Protein in Patients with Pregnancy-Induced Hypertension. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 684-686.
2018, Vol. 35 
