Study of the Correlation Between the Distribution of the Peripheral Red Blood Cell Width and Clinical Prognosis in Elderly Patients with Severe Pneumonia
XU Chuan-qin, CHEN Jian-hui, ZHENG Yu-long, et al
Department of Respiratory Medicine, Second People's Hospital, Huai'an 223002, China
Abstract：【Objective】To investigate the correlation between the distribution of red cell distribution width and the prognosis of the severe pneumonia of the elderly patients.【Methods】We performed a retrospective analysis of 74 elderly patients with severe pneumonia in our hospital from June 2013 to December 2015. According to the survival of discharge, the patients were divided into the survival group and death group. The records included gender, age, acute physiology and chronic heath evaluationⅡ (APACHE Ⅱ) score, WBC, HCT, MCV, Hb, PLT and PDW. RDW on day 1, 3, and 7 were collected as well. Multivariate regression analysis of clinical prognostic factors was conducted.【Results】The mean RDW of d1, d3and d7in the death group increased gradually, however, the mean value of RDW of d1, d3and d7did not show a linear trend in the survival group. Multivariate regression analysis showed that age, APACHE II score, RDW and progressive elevation of RDW were the independent risk factors of severe pneumonia in the elderly patients (P＜0.05).【Conclusion】RDW was the independent risk factors for the mortality of severe pneumonia in the elderly patients, and the progressive increase of RDW suggests a poor prognosis.
徐传芹,陈建辉,郑玉龙,何远强,万玉峰. 老年SCAP患者外周血红细胞体积分布宽度与临床预后的相关性分析[J]. 医学临床研究, 2018, 35(4): 682-683,686.
XU Chuan-qin, CHEN Jian-hui, ZHENG Yu-long, et al. Study of the Correlation Between the Distribution of the Peripheral Red Blood Cell Width and Clinical Prognosis in Elderly Patients with Severe Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 682-683,686.
[1] 赵焕.年龄与老年重症肺炎患者短期和长期死亡率的相关性[J].中国老年学杂志,2012,32(11):2285-2288. [2] 徐传芹.APACHE Ⅲ评分及氧合指数对老年重症肺炎预后影响的分析[J].临床肺科杂志,2012,17(1):41-42. [3] Forhecz Z,Gombos T,Borgulya G,et al.Red cell distribution width in heart failure:prediction of clinical events and relationship with markers of ineffective erythropoiesis,inflammation,renal function,and nutritional state[J].Am Heart J,2009,158(4):659-666. [4] 蔡柏蔷.2007年美国感染病学会/美国胸科学会成人社区获得性肺炎诊治指南解读[C].第六届中国呼吸医师论坛论文集.2007:63-68. [5] 朱川,尹昌林,周人杰.APACHEⅡ评分对重症急性胰腺炎患者行高容量血液滤过治疗时机选择的价值[J].重庆医学,2012,41(23):2371-2373. [6] Tertemiz KC,Ozgen Alpaydin A,Sevinc C,et al.Could “red cell distribution width” predict COPD severity[J].Rev Port Pneumol,2016,22(4):196-201. [7] Montagnana M,Danese E.Red cell distribution width and cancer[J].Ann Transl Med,2016,4(20):399-410. [8] Braun E,Kheir J,Mashiach T,et al.Is elevated red cell distribution width a prognostic predictor in adult patients with community acquired pneumonia [J] ?BMC Infect Dis,2014,14:129. [9] Lee JH.Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia[J].Am J Emerg Med,2013,31(1):72-79. [10] 陈翀.不同细胞因子在重症肺炎诊断中的临床意义[J].医学临床研究,2014,31(6):1169-1171. [11] Lippi G,Dipalo M,Teti L,et al.Relationship between red blood cell distribution width and prognostic biomarkers in patients admitted to the emergency department with acute infections[J].Eur J Intern Med,2013,24(2):15-16. [12] Piagnefelli M,Boudjehia Kz,Brohee D,et al.Alterations of red b1ood cell shape and sialic acid membrane contentin in septic patients[J].Crit Care Med,2003,31(8):2156-2162. [13] 陈绵军,陈军,谭德敏,等.老年重症肺炎患者病原学分布及死亡危险因素分析[J].中国热带医学,2017,17(9):915-920.
2018, Vol. 35 
