Abstract：【Objective】To investigate the correlation between the levels of D-dimer (D-D) and C-reactive protein (CRP) and the incidence of deep venous thrombosis (DVT) after tibial internal fixation.【Methods】A retrospective study was conducted. A total of 122 patients of tibial fracture treated by internal fixation in our hospital were selected as the experimental group. In addition, 122 healthy adults in the same period were selected as the control group. The D-D and CRP levels in the two groups were compared, and the incidence of thrombosis in D-D and CRP patients at different levels were analyzed to reveal the relationship between D-D and CRP levels and the occurrence of DVT.【Results】The postoperative D-D and CRP levels in the experimental group were significantly higher than those before surgery, and were significantly higher than those in the control group. The differences were statistically significant (P<0.05). The incidence of postoperative thrombosis in the experimental group was positively correlated with D-D and CRP levels. When D-D>600 ug/L and CRP>50 mg/L, the incidence of DVT reached about 15%.【Conclusion】The incidence of deep venous thrombosis after the internal fixation of tibial fracture is positively correlated with D-D and CRP levels, which can be a clinical predictor for DVT incidence.
蒋晖,田佳林,谭海鹰. D-D、CRP水平与胫骨骨折内固定术后深静脉血栓发生率的相关性[J]. 医学临床研究, 2018, 35(4): 664-666.
JIANG Hui, TIAN Jia-lin, TAN Hai-ying. Correlation of D-dimer and C-reactive protein protein Levels with the Incidence of Deep Venous Thrombosis after Internal Fixation of Tibial Fractures. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 664-666.
[1] 孙毅,程慎令.桃红四物汤预防胫骨骨折髓内钉内固定术后下肢深静脉血栓发生的临床观察[J].中国药房,2012,23(43):4103-4105. [2] Owings JT,Gosselin RC,Andeson JT,et al.Practical utility of the D-dimer assay for excluding thromboembolism in severely injured trauma patients [J].J Trauma,2001,51(3):425-430. [3] Elias A,Cazanave G,Nguyen F,et al.Comparison of the diagnostic performance of three soluble fibrin monomer tests and a D-dimer assay in patients with clinically suspected deep vein thrombosis of the lower limbs[J].Haematologica,2004,89(4):499-501. [4] 司文腾,张华果,白玉,等.脊柱术后血浆D-二聚体浓度变化与深静脉血栓的关系研究[J].中国骨伤,2014 ,27(5):405-408. [5] 孙宁,杨帆,李宇能,等.新鲜下肢骨折术前深静脉血栓形成危险程度评分量表初探[J].中华外科杂志,2015,53(2):101-105. [6] 周贤杰,罗从风,周明,等.CRP与多发骨折创伤控制二次手术时机相关性的研究[J].中国骨与关节损伤杂志,2010,25(1):13-15. [7] 王簕,杨波,尹飚,等.在腰椎后路内固定术后早期发热患者中监测4种血清感染指标水平的临床意义[J].中国骨伤,2015,28(1):66-70.[8] Mok JM,Pekmezci M,Piper SL.Use of C-reactive protein after spinal surgery:comparison with erythrocyte sedimentation rate as predictor of early postoperative infectious complications [J].Spine,2008,33(4):415-421. [9] Scherer MA,Neumaier M,Von Gumppenberg S.C-reactive protein in patients who had operative fracture treatment [J].Clin Orthop Relat Res,2001,(393):287-293. [10] Wu ZJ,He JL,Wei RQ,et al.C-reactive protein and risk of fracture:a systematic review and dose-response meta-analysis of prospective cohort studies[J].Osteoporos Int,2015 ,26(1):49-57. [11] 刘清高,陈文革.术前D-二聚体、纤维蛋白原、血小板及超敏C-反应蛋白在创伤骨折中的评估价值[J].医学临床研究,2017,34(7):1385-1387.
2018, Vol. 35 
